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Tenofovir disoproxil fumarate, a prodrug of the nucleotide reverse transcriptase inhibitor, tenofovir (9-[9(R)-2-(phosphonomethoxy)propyl]adenine; PMPA), was recently approved for use in the combination therapy of human immunodeficiency virus (HIV)-1 infection.
PMPA demonstrated minor synergistic inhibition of HIV replication in combination with ddI and nelfinavir (and adefovir). All other combinations showed additive ...
May 29, 2020 · An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines · Article Views · Altmetric · Citations.
Apr 11, 1997 · PMPA belongs to a class of antivirals called nucleotide analogues, which are being developed by Gilead for the treatment of viral diseases.
The anti-HIV nucleotide analogue PMPA can be prepared on a kilogram-scale by a three step sequence: i) condensation of adenine with (R)-propylene carbonate, ...
Tenofovir disoproxil fumarate, a prodrug of the nucleotide reverse transcriptase inhibitor, tenofovir (9-[9(R)-2-(phosphonomethoxy)propyl]adenine; PMPA), ...
9-(2-phosphonomethoxypropyl)adenine (PMPA) has demonstrated remarkable anti-simian immunodeficiency virus (SIV) activity in macaque models of SIV infection ...
May 7, 1997 · PMPA has shown unprecedented antiviral activity in the prophylaxis and treatment of simian immunodeficiency virus (SIV) infection, a primate ...
May 29, 2020 · An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines · Article Views · Altmetric · Citations.
May 6, 2014 · The PMEA prodrugs showed more antiviral efficacy than those of PMPA but given the much poorer antiherpetic activity of PMPA versus PMEA, the ...